Born in São Paulo in 1995, Matheus Mello first came into contact with music through his father, an opera singer and pianist. At the age of 11, he began studying the cello at the São Paulo Free Music University, then at the São Paulo Orchestra Music Academy with Wilson Sampaio. After winning several prizes, he left Brazil in 2016 to continue his training at the Haute École de Musique de Genève with David Pia. When he arrived in Switzerland, his talent was quickly recognised; he won a “Mention” at the Concours d’interpretation musicale de Lausanne in 2017, the first prize of the André-François Marescotti Foundation in 2019, and was supported by foundations such as Wilsdorf, Barbour and Schenkel. He has taken part in masterclasses with renowned cellists such as François Guye, Sol Gabetta, Peter Wispelwey, Daniel Müller Schott and Natalie Gutman, as well as with Baroque music specialists such as Tom Koopman, Sigiswald Kuijken and the Quatuor Mosaïque.

In 2024, his fascination with Bach led him to specialise in baroque cello with Bruno Cocset.

Since April 2026, Mello has been principal cellist with the Sorbian Chamber Orchestra in Germany and teaches at the Kreismusikschule Bautzen. His orchestral experience includes performing as principal cello with the Orchestre Sinfonietta de Genève, working as a substitute with the Orchestre de la Suisse Romande and Berner Symphonieorchester, and appearing as a guest player with the Münster Symphoniker, Orchestre National Avignon Provence, Orchestre Philharmonique du Luxembourg, Gli Angeli Genève, and São Paulo Symphony Orchestra .

In chamber music, Mello has performed with renowned soloists from the Berlin, Vienna and Munich Philharmonic Orchestras, such as Radek Baborak, Andreas Ottensamer, Wilfred Strehle, Lorenz Nasturica-Herschcowici, Franz Bartolomei and the Orchestre de la Suisse Romande, Dmitry Rasul-Kareyev and Saya Hashino. Mello is a regular guest at the Grafenegg Festival in Austria.

He plays a late 18th-century Nicolas Lupot cello and a 1745 Jean-Baptiste Ouvrard Baroque cello.